K. I. Kiselev

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Local voltage clamping was applied to mouse macrophage plasma membrane to study calcium channels activated by inositol-1,4,5-triphosphate (IP3) and blocked by heparin. These channels were clearly distinguished from IP3-activated channels of the endoplasmic reticulum by their low conductivity (about 1 pSm for 100 mM Ca2+), high selectivity for Ca2+ relative(More)
Application of 0.2-15.0 mM inositol 1,4,5-trisphosphate (IP3) to excised plasma membrane patches from A 431 cells induced activity of low conductance channels that were highly selective for Ca2+ and Ba2+. With 100 mM Ca2+ or 105 mM Ba2+, the channel conductance was 1.1 pS for the minor conductance substrate. The dose response curve gave an apparent binding(More)
Using patch-clamp technique we have shown that the plasma membrane of mouse macrophages contains calcium channels that are activated by inositol (1, 4, 5)-trisphosphate (IP3) and blocked by heparine. Their conductivity properties strongly differentiate them from IP3-activated channels of endoplasmic reticulum, but make it possible to include them to the(More)
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