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Apolipoprotein E from human serum shows a genetic polymorphism determined by two autosomal codominant alleles, Apo En and Apo Ed. Homozygosity for the gene Apo Ed (phenotype Apo E-D) results in primary dysbetalipoproteinemia, but only some individuals with this phenotype develop gross hyperlipidemia (hyperlipoproteinemia type III). Vertical transmission of(More)
Forty-eight patients (20 diabetic, 28 nondiabetic) with angiographically confirmed peripheral vascular disease (PVD) were examined to discover whether the measurement of pulse reappearance time (PRT) during reactive hyperemia is a more useful method than the measurement of peripheral systolic blood pressure (ankle pressure index; API) for making a specific(More)
In a controlled study on 121 patients with peripheral vascular disease (PVD) (75 patients with primary hyperlipoproteinemia, 15 diabetics, 31 patients without metabolic disease) the relationship between risk factors (hyperlipoproteinemia, obesity, hypertension, abnormal glucose tolerance, smoking) and the degree and localisation of sclerotic lesions was(More)
Fifty-four patients with angiographically confirmed peripheral vascular disease (PVD) were examined in order to find out whether the occlusive form of this disease can be better diagnosed by measuring the reappearance time and mean velocity of the blood flow during reactive hyperemia than by determining the peripheral systolic blood pressure, using Doppler(More)
Three probands heterozygous for a mutant of apolipoprotein AI (apo AIMarburg, Utermann et al. 1982a) were detected by screening of 2282 unrelated individuals resulting an a frequency estimate of about 1/750 in the German population. All three probands with apo AIMarburg had hypertriglyceridemia (triglyceride above 250 mg/dl) and subnormal HDL-cholesterol(More)
In 106 type II diabetics with persisting hyperlipidemia (i.e persistently increased triglycerides >200 mg/dl during intensive diabetes therapy) the Apo E polymorphism was examined in relation to IDDM (n=68) and NIDDM (n=38). It was shown that Apo E2 phenotypes are more (22.6% vs. 14.5%,p<0.05) and Apo E3 phenotypes less frequent in type II diabetics than in(More)
Insulin has an exacerbating effect on endogenous hypertriglyceridemia. Experiments were carried out in order to study the acute effects of insulin in 6 patients with endogenous hypertriglyceridemia and 6 controls. 0.1 Unit insulin/kg body weight was injected into the portal vein. Blood samples were taken from the portal and hepatic veins and analysed for(More)
Decrease in gall-bladder surface area, as obtained by ultrasound, was measured in 52 patients with insulin-dependent diabetes (27 with and 25 without autonomic neuropathy) 60 minutes after administration of the bile stimulant Biloptin. The post-stimulation area was 33 +/- 6% of initial value in patients with autonomic neuropathy, and 67 +/- 8% (P less than(More)
Gastric emptying following the ingestion of 200 ml orange juice was investigated sonographically in 24 insulin-dependent diabetics with and without autonomic neuropathy and in 11 control subjects. Furthermore, the relationship between emptying and blood glucose was determined. The duration of gastric emptying in all patients was negatively correlated with(More)
The apoprotein composition of the main lipoprotein fractions (VLDL, LDL-1, LDL-2 and HDL) was studied initially in 15 patients with Broad-beta disease. Analytical isoelectric focusing of urea-soluble apo-VLDL and apo LSL-1 demonstrated a variant pattern of the polymorphic Apoprotein E with a deficient Apo E-III band in all patients. The Apo E-III deficiency(More)