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The enzymatic determination of sialic acid, commercially introduced recently as an end point method, has been considerably improved by the development of initial rate and peak rate modifications of the kinetic method, respectively, and adapted to a centrifugal analyser (Cobas Bio). The assay is completed within 3 min, takes 3 microliter sample volume and is(More)
OBJECTIVE To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or after a short delay. METHODS Participants in BENEFIT (Betaferon/Betaseron in Newly Emerging MS for Initial Treatment) were randomly assigned to receive interferon beta-1b (early treatment) or placebo (delayed treatment). After(More)
The concentrations of sialic acid in the serum of patients with benign and malignant diseases were determined and the criteria of diagnostic validity (sensitivity, specificity, efficiency, likelihood ratio, predictive values) were calculated. The concentrations of sialic acid in sera of patients with benign diseases (median 0.826 g/l, 5. percentile 0.62(More)
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