K Golombiowska-Nikitin

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The binding of 3H-spiroperidol to striatal membranes from a strain of mutant Han-Wistar rats was compared with that in normal littermate animals. The specific binding was less in the mutants than the controls. Scatchard analysis revealed that the KD- and Bmax-values for the high affinity binding sites in the mutants are greater than for those in the(More)
Experiments are reported which show that 1,3-dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) does not influence the binding capacity of a variety of tritiated ligands to rat brain membranes thus suggesting that the drug does not interact with dopamine, opioid, GABA, alpha 1- and alpha 2-adrenergic receptors, but can influence with low potency(More)
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