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Ca current (ICa) was measured by whole-cell voltage clamp in single cells isolated from frog ventricle, in which the Na current was inhibited by tetrodotoxin (0.3 microM) and K currents were blocked by substituting K with 120 mM intracellular and 20 mM extracellular Cs. The influence of stimulation by ATP (0.1-100 microM) was assessed in the presence of(More)
Changes in the Ca current, ICa, evoked by ethanol, long chain alcohols (hexanol, octanol and dodecanol) and two halogenated anesthetics (chloroform and halothane) were studied in single isolated frog ventricular cells using the whole cell patch clamp technique. Each of these general anesthetics induced a concentration-dependent decrease in ICa which was(More)
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