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This study investigates the behavioral effects of morphine administration and exposure to high ambient pressure in the formalin test. Rats were simultaneously given formalin (0.1 ml, 5%) in a hind paw, and saline or morphine (2.5-10.0 mg/kg) subcutaneously. They were then exposed to ambient pressure of either 1 or 48 bar (compression rate: 3 bar/min; 1 bar(More)
Convulsant doses of penicillin and elevated ambient pressure of 41 bar enhance the excitability of neurons. Their effects have been studied in neostriatal tissue with methods allowing differentiation between transmitter and metabolic glutamate pools. Levels of glutamate (Glu), glutamine (Gln), aspartate (Asp); gamma-aminobutyric acid and taurine were(More)
The effects of morphine and fentanyl on respiration and tissue CO2 measured transcutaneously were studied at surface and at 41 bar ambient pressure in conscious, trained rats. Morphine and fentanyl were given in equianalgesic doses i.v., 7 and 0.025 mg/kg, respectively. Fentanyl caused a rapid but brief respiratory depression which was the same at 1 and 41(More)
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