K. E. Giles

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—Suppose there is a need to swiftly navigate through a spatial arrangement of possibly forbidden regions, with each region marked with the probability that it is, indeed, forbidden. In close proximity to any of these regions, you have the dynamic capability of disambiguating the region and learning for certain whether or not the region is forbidden—only in(More)
The 16 kb heterochromatin domain between the chicken β-globin locus and the folate receptor gene is used here to study the roles of RNA dependent mechanisms and histone modifications in maintenance of a constitutively heterochromatic structure. Inhibition of HDAC activity is shown to both increase intergenic transcription and render the heterochromatin more(More)
Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentiation is not known. Here we report that Usp16, a histone H2A deubiquitinase, regulates H2A(More)
It has become increasingly clear that proper cellular control of pluripotency and differentiation is related to the regulation of rRNA synthesis. To further our understanding of the role that the regulation of rRNA synthesis has in pluripotency we monitored rRNA synthesis during the directed differentiation of human embryonic stem cells (hESCs). We(More)
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