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Interleukin-8 (IL8) is believed to play a role in the pathogenesis of bronchiolitis, a common viral disease of infancy, and a recent U.K. family study identified an association between this disease and the IL8-251A allele. In the present study we report data, from a different set of families, which replicate this finding; combined analysis of 194 nuclear(More)
BACKGROUND The nature of the association between severe respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing remains unknown. In a previous study, we showed that genetic variation in the IL-8-promoter region is associated with susceptibility to severe bronchiolitis. OBJECTIVE The purpose of this study was to assess the association(More)
This paper concerns the inertial deposition of aerosol particles in models of human branching airways. Homogeneous monodisperse aerosols of known characteristics were generated using a spinning disc atomizer. These were paused through simple bend systems of differing geometries, and the fractional deposition measured by a fluorimetric technique. The(More)
The reproducibility of pulmonary function tests in the laboratory and in a mobile field survey vehicle has been studied. Groups of laboratory workers were studied at base and a random sample of 38 coalminers was examined in the mobile laboratory. The intra-subject variability of some newer tests of lung function, including closing volume and maximum flow at(More)
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