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The relative contribution of several effector systems to a prostaglandin E1-(PGE1) evoked hyperthermia was examined. Infusion of 150 ng of PGE1 into a lateral cerebral ventricle increased core temperature and whole body metabolic rate, brown adipose tissue temperature, systolic blood pressure, and heart rate. Pretreating the animals with a nonselective(More)
BACKGROUND This assessment updates and expands on two previous technology assessments that evaluated implantable cardioverter defibrillators (ICDs) for arrhythmias and cardiac resynchronisation therapy (CRT) for heart failure (HF). OBJECTIVES To assess the clinical effectiveness and cost-effectiveness of ICDs in addition to optimal pharmacological therapy(More)
To investigate the effect of cold water on swimming four men who declared themselves good swimmers were immersed fully clothed on separate days in water at 23.7 degrees and 4.7 degrees C. The time that they were able to swim in the cold water was much shorter than in the warm. The two shortest swims ended after 1.5 and 7.6 minutes, before rectal temperature(More)
Subjects have been immersed in water at 27 degrees C and 10 degrees C and while immersed their respiratory rates, minute volumes, and end-tidal PCO2 levels were measured. Measurements were made with the subjects at rest, exercising at approximately 0.8 liter oxygen-min-1, and very vigorously at 1.8-2.0 liters oxygen-min-1. Immersion in the cold water caused(More)
Resting subjects were immersed for 30 min in water at 22 and 30 degrees C after drinking alcohol. Total ventilation, end-tidal PCO2, rectal temperature, aural temperature, mean skin temperature, heart rate, and oxygen consumption were recorded during the experiments. Blood samples taken before the immersion period were analyzed by gas-liquid chromatography.(More)
Subjects who had not been exercising, were immersed for 20 min in water at 13 degrees C after ingestion of alcohol. During the immersion period, total ventilation, end-tidal PCO2, rectal temperature, aural temperature, and mean skin temperature were recorded. Control experiments were carried out at the same water temperature. Blood samples (3 ml), taken(More)