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647 trical engineering, and biomedical informatics. In particular this book reflects the long-term continuous endeavors of a research group conducting innovatory research and could provide useful hints to novices in the related fields. The theory and practice of pattern recognition is a broad field, and the authors address one of the most important issues(More)
We developed a multiplexed label-free quantification strategy, which integrates an efficient gel-assisted digestion protocol, high-performance liquid chromatography tandem MS analysis, and a bioinformatics alignment method to determine personalized proteomic profiles for membrane proteins in human tissues. This strategy provided accurate (6% error) and(More)
BACKGROUND Survivin is a member of the family of inhibitor of apoptosis proteins that is overexpressed in several human tumors. Previous studies have found that overexpression of survivin in cancer cells induces an antibody response. METHODS We compared 232 serum samples from colorectal cancer (CRC) patients and 365 samples from healthy volunteers using(More)
In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity,(More)
The aim of this study was to uncover the membrane protein profile differences between colorectal carcinoma and neighboring normal mucosa from colorectal cancer patients. Information from cellular membrane proteomes can be used not only to study the roles of membrane proteins in fundamental biological processes, but also to discover novel targets for(More)
BACKGROUND Annexins (ANXAs) belong to a superfamily of closely related calcium and membrane-binding proteins and are overexpressed in some carcinomas. The overexpression of ANXAs presumably induces an autoantibody response, but this has not been demonstrated for sera from colorectal cancer (CRC) patients. STUDY We examined serum samples from 220 CRC(More)
The etiology of chronic obstructive pulmonary disease (COPD) remains unclear. A mechanism involving the autoimmune reaction in the pathogenesis of COPD has been proposed but not confirmed. The aim of this study was to investigate whether serum autoantibodies against pulmonary cellular proteins are present in COPD patients and to identify their autoantigens(More)
Pattern recognition is a process of description, grouping, and classification of patterns. A pattern is an entity that could be associated with a name. In a real-world pattern recognition problems in diversified forms are ubiquitous and are critical in most human decision making tasks. In terms of information availability there are two general paradigms for(More)