K. C. Yan

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Iptakalim hydrochloride, a novel cardiovascular ATP-sensitive K(+) (K(ATP)) channel opener, has shown remarkable antihypertensive and neuroprotective effects in a variety of studies using in vivo and in vitro preparations. We recently found that iptakalim blocked human alpha4-containing nicotinic acetylcholine receptors (nAChRs) heterologously expressed in(More)
Contactin associated protein (Caspr), an adhesion molecule, plays roles in formation of paranodal junctions in myelinated axons, neurite outgrowth, synaptic plasticity in nervous system. Here we have shown a novel function of Caspr in pathogenesis of Alzheimer's disease (AD). Caspr distributes around amyloid plaques in APP/PS1 mice. Levels of Caspr increase(More)
In the title compound, C14H12N2O3, the pyridine ring is twisted with respect to the phenyl ring and the carb-oxy-lic acid group at angles of 37.1 (5) and 8.1 (3)°, respectively; the phenyl ring forms a dihedral angle of 41.4 (1)° with the mean plane of the C-NH-C=O fragment. An intra-molecular O-H⋯O hydrogen bond occurs between the carb-oxy-lic acid and(More)
The program SCANGRAPH has been developed for vectorizing any drawing or graph in the form of a single continuous line. With the use of the software, the raster image of a graph in the TIFF format as generated from an optical scanner or digitizing video system can be converted to the corresponding digitized graph with x and y coordinates given. The digitized(More)
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