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OBJECTIVES Several reports suggest that enhanced generation or actions of nitric oxide (NO) have been implicated in the pathogenesis of glomerular hyperfiltration and hyperperfusion that occurs in early diabetes. However, the precise role of altered NO generation in the pathogenesis of diabetic nephropathy is unclear. The present study was aimed at(More)
BACKGROUND/AIMS Continuous renal replacement therapy (CRRT) has been widely used for treating critically ill patients with acute kidney injury (AKI). Whether CRRT is better than intermittent hemodialysis for the treatment of AKI remains controversial. We sought to identify the clinical features that can predict survival for the patients who are treated with(More)
OBJECTIVES Central and peripheral roles of nitric oxide (NO) in blood pressure regulation have been suggested. The present study was aimed at examining if the role of NO in blood pressure regulation is altered in chronic renal failure. METHODS Blood pressure responses to acute inhibition of NO were examined in 5/6 nephrectomized rats. Three weeks after(More)
The hippocampus contains a high concentration of the two corticosterone (CT) receptor subtypes, i.e. the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). The endogenous steroid hormone CT has tenfold higher affinity for the MR than the GR. Under physiological conditions the MR is 80-95% occupied; during the daily diurnal surge of CT and(More)
5-hydroxytryptamine (5-HT) hyperpolarizes hippocampal pyramidal cells in both areas CA1 and CA3 through an increase in potassium conductance. The receptor mediating the hyperpolarization in CA1 has been characterized as the 5-HT1A receptor, but has not been identified in area CA3. Intracellular recording techniques were used to record from CA1 and CA3(More)
Fluoxetine is a 5-hydroxytryptamine (5-HT, serotonin)-selective reuptake inhibitor (SSRI) and is one of the main drugs used for the treatment of depression. Because it takes 2 to 3 weeks of treatment before clinical efficacy is manifest, the acute actions of fluoxetine cannot account for the clinical actions of the drug. The chronic effects of fluoxetine(More)
The hippocampus contains interneurons that release gamma-aminobutyric acid (GABA). GABA hyperpolarizes hippocampal CA1 and CA3 pyramidal cells through activation of GABAB postsynaptic receptors. GABAB and 5-hydroxytryptamine1A (5-HT1A) receptors share effector mechanism(s). Agonist potency and the maximal hyperpolarization produced by 5-HT1A receptor(More)
A 29-year-old woman presented with bloody diarrhea, abdominal pain, hemolytic anemia, thrombocytopenia, and acute renal failure. She was diagnosed with Escherichia coli O104:H4-associated hemolytic-uremic syndrome (HUS) and treated with plasmapheresis and hemodialysis for 3 weeks. She recovered without sequelae. To the best of our knowledge, this is the(More)
In the present study we report the results of 200 percutaneous internal jugular vein catheterizations for hemodialysis performed at our center in 161 patients, 95 males and 66 females with a mean age of 39.77 +/- 12.9 years (mean +/- SD). 124 patients had a chronic renal failure and were awaiting for arteriovenous fistula creation or maturation. Major(More)
The firing rate of hippocampal pyramidal cells recorded from the CA3 subfield is inhibited by 5-hydroxytryptamine (5-HT, serotonin) or by electrical stimulation of the ascending serotonergic fibers from the raphe. The mechanism of action of this inhibitory effect produced by 5-HT has not been determined. Intracellular recording techniques in the hippocampal(More)