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During ail examination of microbial culture filtrates capable of reversing the inhibition of Streptomyces aureofaciens Strain NRRL B-1286 caused by the metliionine analogue norleucine, one filtrate was found to possess striking reversing potency. Analysis showed this could not be due to methionine. The reversal properties of the filtrate were traced to(More)
Faithful DNA replication is a cornerstone of genomic integrity. PTEN plays multiple roles in genome protection and tumour suppression. Here we report on the importance of PTEN in DNA replication. PTEN depletion leads to impairment of replication progression and stalled fork recovery, indicating an elevation of endogenous replication stress. Exogenous(More)
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