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Most transmembrane proteins are subjected to limited proteolysis by cellular proteases. The recent molecular cloning of the TNF-a converting enzyme (TACE) revealed that this shedding enzyme belongs to a family of metalloproteinases which contain a disintegrin domain (ADAM family). The activity of these proteases seems to be tightly regulated. Mice lacking(More)
A functionally and structurally diverse group of transmembrane proteins including transmembrane forms of mediators or receptors can be proteolytically cleaved to form soluble growth factors or receptors. Recently, the proteolytic activity responsible for pro-tumor necrosis factor alpha (proTNFalpha) processing has been identified and named TACE (TNFalpha(More)
This paper describes a system for in vitro cell migration analysis. Adult neural stem/progenitor cells are studied using time-lapse bright-field microscopy and thereafter stained immunohistochemically to find and distinguish undifferentiated glial progenitor cells and cells having differentiated into type-1 or type-2 astrocytes. The cells are automatically(More)
MOLTKE is a research project dealing with a complex technical application. After describing the domain of CNC machining centers and the applied KA methods, we summarize the concrete KA problems which we have to handle. Then we describe a KA mechanism which supports an engineer in developing a diagnosis system. In chapter 6 we introduce learning techniques(More)
Although regulated ectodomain shedding affects a large panel of structurally and functionally unrelated proteins, little is known about the mechanisms controlling this process. Despite a lack of sequence similarities around cleavage sites, most proteins are shed in response to the stimulation of protein kinase C by phorbol esters. The signal-transducing(More)
Contrast-echocardiography in conjunction with realtime video-densiometry can be an effective means of studying right ventricular (RV) structural changes, e.g. in patients diagnosed with Arrhythmogenic Right Ventricular Dysplasia (ARVD). In order to characterize RV flow pattern it may be necessary to track the front of the contrast agent as it enters the RV.(More)
This paper evaluates the performance of two methods, level set active contours and watershed region growing, applied to live cell image segmentation. These methods suffer from opposite problems. As the level set method tends to merge clustered cells, the watershed method often results in oversegmentation. These problems can be reduced by adding an image(More)
Due to the ever increasing demands of the market, strategic management of knowledge assets, or ,EARNING /RGANIZATIONS (LOs), are becoming a must in industrial software development. This paper presents work done at Fraunhofer IESE, where LOs for software development organizations are being developed and transferred into industrial practice. It describes how(More)
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