Kôzô Hayashi

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Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they do not fully recapitulate the pathophysiology of human PARK2. Here, we(More)
We present two diagnostically challenging cases of acute pancreatitis with hypertriglyceridemia accompanied with chylomicronemia caused with a deficiency of lipoprotein lipase and with the presence of type V hyperlipidemia. Both cases suffered from acute abdomen following the ingestion of fatty food and revealed the increase in parameters of inflammation(More)
Transport of L-proline, L-leucine and L-cysteine was studied in brush border membrane vesicles prepared from guinea pig ileum. Concentrative transport of L-proline, L-leucine and L-cysteine was obtained in the presence of an Na+ gradient from, outside to inside of the vesicles, which indicated contribution of either system A (alanine-preferring) or system(More)
BACKGROUND The D allele of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and coagulation activity play important roles in cardiovascular events, however, the precise association between these two risk factors remains unclear. METHODS We identified the ACE I/D genotype and measured the plasma coagulation factor VII and X (FVII(More)
BACKGROUND Helicobacter pylori stool antigen (HpSA) test is a new tool for evaluating the H. pylori infection. The present study was carried out to investigate the clinical usefulness of the HpSA test in the evaluation of eradication therapy by comparing it with the (13)C-urea breath test (UBT). METHODS One hundred and five patients received eradication(More)
The proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the formation of atherosclerotic lesions and restenosis after angioplasty. It has been suggested that probucol inhibits VSMCs proliferation, but this effect has not been directly demonstrated. In this study we investigated the effect of probucol on neointimal formation(More)
The effects of cerivastatin sodium (BAY w 6228), a new type of inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on plasma cholesterol concentrations and the induction of hepatic LDL receptors were investigated with beagle dogs and Hep G2 cells. Oral administration of cerivastatin (0.01, 0.03, and 0.1 mg/kg per day) for 3 weeks reduced(More)
Red pigmented bodies were found in tepal cells of threeRebutia species, i.e.,R. grandiflora, R. hyalacantha andR. krainziana. The pigmented body within the vacuole was spherical and normally one per cell. It contained betalains which were validated from the visible spectra of tepal extracts and microspectrophotometric survey on vacuoles. Such a particular(More)
A purplish-blue anthocyanin was isolated from the flower of garden cineraria (Senecio cruentus DC.). The pigment retains a stable blue color within the range of pH 3.5-7; but it differs in other characteristics from the known blue anthocyanins. This pigment is composed of delphinidin, glucose and caffeic acid in a molecular ratio of 1∶3∶2, respectively and(More)
Following some surveys of anthocyanins in the flowers, fruits and autumnal leaves of plants in the flora of Japan (Hayashi and Abe, 1935, 1955, 1956; Ueno, el al., 1969; Shibata, et al., 1967), an attempt has been made to clarify the nature of the red pigments appearing in the sprouting leaves of a variety of plants in early spring. This paper deals with(More)