Kátia Kaori Otaguiri

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Human multipotent mesenchymal stromal cells (MSC) display immunoregulatory functions that can modulate innate and adaptive cellular immune responses. The suppressive and immunomodulatory activities of MSC occur by the action of soluble factors that are constitu-tively produced and released by these cells or alternatively , after induction of MSC stimuli in(More)
HAM/TSP is an inflammatory manifestation of central nervous system caused by HTLV-1 and the mechanism of HAM/TSP development is no well elucidated. Currently , a promising approach on the physiopathogenesis of viral infections has been the evaluation of microRNAs (miRNAs) role. There are few data involving CD4+ T cells miRNA expression in HTLV-1 infection(More)
Accurate diagnostic tests are powerful tool to control the spread of the human T-lymphotropic virus (HTLV) infection. In Brazil, the currently applied diagnostic algorithm for HTLV-1/2 screening is based on serologi-cal tests (enzyme-linked immunosorbent assay followed by Western Blot). However this algorithm is unsuitable due to its high cost and the(More)
The characterization of cell types that are susceptible to HTLV-1 infection is essential to understand of the biology of virus infection and the pathophysiology of HTLV-related diseases. In the present study, we investigated bone marrow (BM) cells from asymptomatic carriers (HAC) and symptomatic HTLV-1 individuals. Initially, we observed an infiltrated of(More)
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