Learn More
The neuroligin (NL) gene family codes for brain specific cell adhesion molecules that play an important role in synaptic connectivity. Recent studies have identified NL mutations linked to patients with autism spectrum disorders (ASD). Cognitive deficits seen in autistic patients are hypothesized to arise from altered synchronicity both within and between(More)
Autism Spectrum Disorder (ASD) is often found to co-exist with non-core behavioral manifestations that include difficulties in disengagement of attention to sensory cues. Here we examined whether this behavioral abnormality can be induced in rats prenatally exposed to valproic acid (VPA), a well-established teratogen associated with ASD animal models. We(More)
OBJECTIVE Articular cartilage matrix vesicles generate calcium pyrophosphate- and basic calcium phosphate-like mineral in vitro. We sought to determine the morphologic features and calcifying capacity of sodium nitroprusside (SNP)-induced vesicles for comparison to those of controls. METHODS Porcine articular cartilage was exposed to 1 mM SNP for 24 h and(More)
Introduction For more than a decade, the Iowa gambling task (IGT) [1, 2] has been utilized to test numerous mental deficits induced by neurological damage or psychiatric disorders[3]. The IGT has recently been standardized for testing 13 different neuropsychological disorders. Moreover, the IGT is now published and sold by the PAR, Inc., as a(More)
  • 1