Jyrki Penttinen

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BACKGROUND In 1992 Thorogood et al. reported an increased risk of myocardial infarction in women using psychotropic drugs. The aim of our study is to find out whether there is a link between the use of psychotropic drugs and subsequent myocardial infarction in males. METHOD A cohort of 3172 male farmers was followed from 1 February 1980 to 31 December(More)
Low-density lipoproteins, infections and smoking are closely associated with insulin resistance. According to the hypothesis proposed in this paper, all of these factors could cause insulin resistance by the same mechanism. The first step in the cascade of events leading to insulin resistance is increased production of interleukin-2. This is followed by(More)
An excess mortality for violence (suicides and injuries) has been observed following the use of cholesterol-lowering drugs. It has been suggested that low cholesterol is associated with depression by modifying the serotonin metabolism. In this paper, a new hypothesis concerning the association among serum lipids, depression, and atherosclerosis is proposed.(More)
This study examines the relationship between traditional risk factors of coronary artery disease and indicators involved in the metabolism of L-arginine (plasma and urine L-arginine, plasma L-citrulline, serum creatinine and urine orotic acid). Our study population consisted of 40 healthy male volunteers aged between 35 and 55 years. We found an inverse(More)
Vital reactions in the paw skin of guinea pigs dying of hypothermia were examined using a variety of histochemical methods to find ways of distinguishing between ante-mortem and post-mortem frostbites. Some animals were treated with ethanol or diazepam. Edema, hyperemia, and incipient accumulation of granulocytes were seen to develop within the 2-6 h for(More)
The aim of this trial was to determine whether social interaction between patients with long-lasting nonspecific back pain reduces subjective or objective disability. The participants were selected from persons visiting an occupational health care unit because of back pain. After a clinical examination in a university clinic, subjects without a specific(More)
OBJECTIVES This study determined whether people visiting a doctor because of infection had an increased risk of myocardial infarction. METHODS For 83 case patients and 249 matched control patients nested in a cohort of 3172 Finnish male farmers, comparisons were made on the basis of visits to a doctor because of infection. RESULTS Infections of the(More)
An acute ethanol dose of 2 g/kg shortened the survival time at -20 degrees C of guinea pigs both adapted to the cold and those reared in the warm, but no significant difference was observed between the adapted and non-adapted groups. Long-term ethanol treatment of 2 g/kg/day for 4 weeks, lengthened the survival time of the guinea pigs reared at room(More)