Jyoti Joshi

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It is well established that visceral leishmaniasis (VL; also known as Kala azar) causes immunosuppression, and a successful drug treatment is associated with the development of cell-mediated immunity. Therefore combining a drug with an immune enhancer can provide a better approach for the treatment of the disease. Keeping this in mind, the in vivo(More)
Visceral leishmaniasis (VL) represents the second most challenging infectious disease worldwide, leading to nearly 500,000 new cases and 60,000 deaths annually. Ninety per cent of VL cases occur in five countries namely Bangladesh, India, Nepal, Sudan and Brazil. No licensed vaccine is available till date against any form of leishmaniasis. High toxicity and(More)
The present work was carried out to study the occurrence of Y. enterocolitica in different samples in and around Chandigarh, India. 495 stool samples from diarrheal patients were collected for bacterial isolation. To identify the bacteria belonging to family Enterobacteriaceae, the samples were cultured on MA (MacConkey Agar), XLD (Xylose lysine(More)
OBJECTIVE To analyze the protective efficacy of recombinant 78 kDa antigen of Leishmania donovani in combination with two adjuvants, that is, cationic liposomes or MPL-A against visceral leishmaniasis in BALB/c mice. METHODS The genomic DNA of promastigotes was isolated and 583 bp of T cell epitopes of gene encoding 78 kDa was amplified using specific(More)
The synthesis and characterization of aromatic alcohols such as 1-(4-bromo phenyl) ethanol, 1-(4-Hydroxy-3-methoxyphenyl) ethanol, (4-Hydroxy-3-methoxy-benzyl alcohol) employing biotransformation (using whole cells of Baker’s Yeast in their free as well as immobilized form in mixtures of glycerol and water) and Electrochemical technique are reported. The(More)
The current study was designed to examine the protective efficacy of DNA vaccines based on gp63 and Hsp70 against murine visceral leishmaniasis. Inbred BALB/c mice were immunized subcutaneously twice at an interval of three weeks with pcDNA3.1(+) encoding T cell epitopes of gp63 and Hsp70 individually and in combination. Animals were challenged(More)
Incorporation of green methodology via biocatalytic and electrochemical steps using Baker’s Yeast and electrons as reducing agent respectively have been employed as a novel and efficient route to furnish relevent chiral building blocks for fine chemicals and pharmaceuticals. Reduction of selected ketones such as 2-methylcyclohexanone, 3-methylcyclohexanone,(More)
In the present study, a new species Myxobolus dermiscalis n. sp. infecting scales of Labeo rohita, an Indian major carp from Harike Wetland in Punjab, India has been described on the basis of spore morphology and amplification of a part of 18S rDNA gene. The pseudocysts of M. dermiscalis n. sp. are milky white with irregular outline, 0.5-3.6 mm in diameter(More)
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