Jyothsna Manikkath

Publications16
h-index7
Citations204
Highly Influential Citations3
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Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage
Abstract The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along… Expand
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Supplementing zinc oxide nanoparticles to cryopreservation medium minimizes the freeze-thaw-induced damage to spermatozoa.
The sperm DNA integrity post cryopreservation of human semen samples is one of the serious concerns in human infertility treatment. In the present study, the beneficial effects of zinc oxide… Expand
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Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen.
The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide… Expand
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Skin Delivery of EGCG and Silibinin: Potential of Peptide Dendrimers for Enhanced Skin Permeation and Deposition
The aim of the present study was to evaluate the ability of the peptide dendrimers to facilitate transdermal delivery of antioxidants, silibinin, and epigallocatechin-3-gallate (EGCG). Drug–peptide… Expand
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Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen
Abstract The aim of the present study was to investigate the combined effect of PAMAM dendrimers and low-frequency ultrasound on the transdermal delivery of ketoprofen. Ketoprofen was subjected to in… Expand
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Peptide dendrimer‐conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery
&NA; The aim of this study was to evaluate skin delivery of ketoprofen when covalently tethered to mildly cationic (2+ or 4+) peptide dendrimers prepared wholly by solid phase peptide synthesis. The… Expand
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Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations.
The aim of this study was to improve the pharmacokinetics and pharmacodynamics profile of rosuvastatin calcium by formulating long-circulating PEGylated chitosan nanoparticles (NPs). Chitosan was… Expand
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Skin permeation of gemcitabine hydrochloride by passive diffusion, iontophoresis and sonophoresis: In vitro and in vivo evaluations
Abstract The present study was undertaken to assess skin permeation of gemcitabine hydrochloride (GEM) following passive diffusion, iontophoresis and sonophoresis. In vitro passive diffusion were… Expand
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Delving Deeper into Dermal and Transdermal Drug Delivery: Factors and Mechanisms Associated with Nanocarrier-mediated Strategies.
BACKGROUND Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are… Expand
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Peptide dendrimers in delivery of bioactive molecules to skin
The development of dendrimers as potential drug carriers or scaffolds is currently one of the most active areas of pharmaceutical and biomedical sciences. Peptide dendrimers, an alternative class of… Expand
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