• Publications
  • Influence
Structural Basis of a Flavivirus Recognized by Its Neutralizing Antibody
TLDR
The solution structure of the major antigenic domain (domain III) of the Japanese encephalitis virus (JEV) envelope protein is determined and provides a structural basis for understanding the mechanism of immunologic protection and for rational design of vaccines effective against flaviviruses. Expand
Easy Strategy To Increase Salt Resistance of Antimicrobial Peptides
TLDR
The activities of the salt-sensitive peptide P-113 were diminished at high salt concentrations, whereas the activities of its β-naphthylalanine and β-(4,4′-biphenyl)alanine-substituted variant were less affected. Expand
Stability and peptide binding specificity of Btk SH2 domain: Molecular basis for X‐linked agammaglobulinemia
TLDR
The studies revealed that mutation of R288 and R307 located in the phosphotyrosine binding site resulted in a more than 200‐fold decrease in the peptide binding compared to L295, Y334, Y361, L369, and I370 mutations in the pY + 3 hydrophobic binding pocket. Expand
Solution structure and neutralizing antibody binding studies of domain III of the dengue‐2 virus envelope protein
TLDR
The structure and neutralizing antibody binding studies of domain III of the dengue-2 virus envelope protein reveal a polypeptide-like structure that is similar to that of the Tournaisian virus. Expand
Solution Structure of a Novel Tryptophan-Rich Peptide with Bidirectional Antimicrobial Activity
TLDR
It is determined that the solution structures of Pac-525 bound to membrane-mimetic sodium dodecyl sulfate (SDS) micelles and vesicles, suggesting that the antimicrobial activity ofPac-525 may be due to interactions with bacterial membranes. Expand
Rational Design of Tryptophan‐Rich Antimicrobial Peptides with Enhanced Antimicrobial Activities and Specificities
TLDR
The solution structure of PEM‐2 bound to membrane‐mimetic dodecylphosphocholine micelles by two‐dimensional NMR methods was determined to improve the antimicrobial activity of Pem‐2 for potential clinical applications further. Expand
Identification of a heparin binding peptide from the Japanese encephalitis virus envelope protein
TLDR
An extended form of the JEV domain III protein is prepared with residues ranging from 261 to 402 and its heparin binding sites are identified, providing a basis for further understanding the interactions of flaviviruses and glycosaminoglycans on the host cell surfaces. Expand
Boosting Salt Resistance of Short Antimicrobial Peptides
TLDR
A strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid β-naphthylalanine to their termini is described. Expand
Novel Antimicrobial Peptides with High Anticancer Activity and Selectivity
TLDR
Fluorescence microscopic studies indicated that the FITC-labeled K4R2-Nal2-S1 preferentially binds cancer cells and causes apoptotic cell death, and a significant inhibition in human lung tumor growth was observed in the xenograft mice treated with K4r2- Nal2 -S1. Expand
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3–72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis
TLDR
Investigation of the effect of this ELR-CXC chemokine antagonist G31P on human non-small cell lung cancer cells and lung tumor progression in an orthotopic xenograft model suggests it can inhibit human lung cancer cell growth and metastasis, which offers potential therapeutic opportunities. Expand
...
1
2
3
4
5
...