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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps
The data suggest that induction of NETs by cancer cells is a previously unidentified metastasis-promoting tumor-host interaction and a potential therapeutic target, and treatment with NET-digesting, DNase I–coated nanoparticles markedly reduced lung metastases in mice.
TNFα Mediated IL-6 Secretion Is Regulated by JAK/STAT Pathway but Not by MEK Phosphorylation and AKT Phosphorylation in U266 Multiple Myeloma Cells
Blockage of JAK/STAT-mediated NF-κB activation was highly effective in controlling the growth of MM cells and, consequently, an inhibitor of TNFα-mediated IL-6 secretion would be a potential new therapeutic agent for patients with multiple myeloma.
RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis
Caveolin-1 may confer a growth advantage to cancer cells during DXR chemotherapy and surviving HRCC cells eventually might develop lung metastasis, according to cDNA microarray analysis.
RNA interference-directed knockdown of urokinase plasminogen activator receptor inhibits MMPs expression via dephosphorylation of Erk1/2 and Stat3 in AML
RNA interference-directed targeting of uPAR is a convenient and novel tool for studying the biological role of the uPAR system and suggests the potential of its application for leukemia therapy.
Combination of SK-7041, one of novel histone deacetylase inhibitors, and STI571-induced synergistic apoptosis in chronic myeloid leukemia
SK-7041 is a novel hybrid synthetic histone deacetylase inhibitor derived from the hydroxamic acid of trichostatin A and pyridyl ring of MS-275 that is suggested to be active against leukemia and offers new prospects for overcoming STI571 resistance in chronic myeloid leukemia.
The Tcf21 lineage constitutes the lung lipofibroblast population.
Overexpression of Tcf21 in primary neonatal lung fibroblasts led to increases in intracellular neutral lipids, suggesting a regulatory role for TCF21 in lipofibroblast function.
Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of NPM1 mutation according to subtype
Retrospective medical record review of 106 de novo AML patients lacking FLT3-ITD, who received induction chemotherapy from three centers in Korea between 1997 and 2007, found non-A type NPM1 mutation is a poor prognostic factor.