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This work evaluated doxycycline (2nd generation tetracycline) protection against pilocarpine-induced convulsions in rats. The animals were treated with doxycycline (Dox: 10 to100 mg/kg, i.p., 7days), 30min before the pilocarpine injection (P: 300mg/kg, i.p.) and observed for cholinergic signs, latencies to the first convulsion and death. Amino acid(More)
Fibromyalgia syndrome (FMS) is a mysterious condition with uncertain physiopathogenesis. Despite its hermeneutic problems, FMS and related afflictions are responsible for the majority of family medicine and rheumatological medical office appointments. In spite of the skepticism of some, it seems that the medical science community has accepted FMS as a(More)
PURPOSE The treatment of pediatric patients with malignant brain tumors has evolved considerably in the past decades. However, results are still unsatisfactory for some patients. Valproate has been shown to positively affect the survival of adult glioblastoma patients. We have been giving prophylactic antiepileptic drugs to newly diagnosed children with(More)
Diffuse intrinsic pontine glioma is a pediatric oncologic disease with dismal prognosis and no effective treatment. Since 2007, our patients have been using valproic acid as prophylactic anticonvulsant. We have undertaken a retrospective study in order to evaluate the influence of valproate in the outcomes of children with this disease in our center.(More)
Brain cancer is the second neurological cause of death. A simplified animal brain tumor model using W256 (carcinoma 256, Walker) cell line was developed to permit the testing of novel treatment modalities. Wistar rats had a cell tumor solution inoculated stereotactically in the basal ganglia (right subfrontal caudate). This model yielded tumor growth in 95%(More)
OBJECTIVES To estimate survival and evaluate prognostic factors of pediatric patients with central nervous system (CNS) tumors treated in a single center. METHODS Retrospective analysis of survival of 103 children with primary brain tumors diagnosed consecutively from January 2000 to December 2006. Cox regression was used for multivariate analysis of(More)
from the scans will be independently reviewed and compared in order to evaluate the reproducibility of the micro-MRA technique. The study has been approved by the local institutional review board (IRB) and informed consents have been obtained from all participants. Based on our preliminary results on four healthy volunteers (all females, mean AE S.D. age(More)
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