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OBJECTIVE This study aimed at identifying the impact of subcortical stroke on the interaction of cortical motor areas within and across hemispheres during the generation of voluntary hand movements. METHODS Twelve subacute stroke patients with a subcortical ischemic lesion and 12 age-matched control subjects were scanned using 3-Tesla functional magnetic(More)
BACKGROUND Following the concept of interhemispheric competition, downregulation of the contralesional primary motor cortex (M1) may improve the dexterity of the affected hand after stroke. OBJECTIVE To determine the effects of 1-Hz repetitive transcranial magnetic stimulation (rTMS) of the contralesional M1 on movement kinematics and neural activation(More)
The effects of a 3-week computerised alertness training on chronic (>3 months) visuospatial hemineglect were investigated prospectively in seven patients by means of neuropsychological tests and functional magnetic resonance imaging (fMRI). Following the alertness training, the group showed improved alertness and a significant improvement in the performance(More)
Transcranial direct current stimulation is a painless, non-invasive brain stimulation technique that allows one to induce polarity-specific excitability changes in the human brain. Here, we investigated, for the first time in a 'proof of principle' study, the behavioural effect of transcranial direct current stimulation on visuospatial attention in both(More)
BACKGROUND . Rehabilitation of the severely affected paretic arm after stroke represents a major challenge, especially in the presence of sensory impairment. OBJECTIVE . To evaluate the effect of a therapy that includes use of a mirror to simulate the affected upper extremity with the unaffected upper extremity early after stroke. METHODS . Thirty-six(More)
PURPOSE It has been proposed that the right hemisphere alerting network co-activates, either directly or via the brainstem, the spatial attention system in the parietal cortex. The observation that measures of impaired alertness and sustained attention can be used to predict the outcome of neglect might suggest such a relationship, too. The aim of the(More)
Dexterity was investigated in right-handed subjects in the subacute phase of a first unilateral subcortical middle cerebral artery stroke affecting the left or right hemisphere and right-handed healthy subjects. Dexterity was quantified at both hands by kinematic recordings of finger and hand tapping, a reach-to-grasp movement, quantitative analysis of grip(More)
We prospectively investigated by means of neuropsychological tests and functional magnetic resonance imaging (fMRI) the behavioural and neural effects of a 3-week optokinetic stimulation (OKS) training in 7 patients with chronic visuospatial neglect resulting from right-hemisphere lesions. Behaviourally, OKS caused both a short- and a long-term (4 weeks)(More)
The combined efficacy of space- and alertness related training in chronic hemineglect was tested behaviorally and in a longitudinal fMRI study. Earlier results had shown that both space as well as alertness related training as single intervention methods lead to short term improvement which, however, is not stable for longer time periods. The(More)
Positron emission tomography and functional magnetic resonance imaging are the major techniques of functional brain imaging. Both techniques have been used successfully in studies of the speech-relevant cortex in normal individuals and in aphasic patients with brain lesions. The activation studies basically agree with the classic model of language(More)