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Cathelicidins, like other antimicrobial peptides, exhibit direct antimicrobial activities against a broad spectrum of microbes, including both Gram-positive and Gram-negative bacteria, enveloped viruses, and fungi. These host-derived peptides kill the invaded pathogens by perturbing their cell membranes and can neutralize biological activities of endotoxin.(More)
Archaea have been detected in several ecological niches of the human body such as the large intestine, skin, vagina as well as the oral cavity. At present, archaea are recognized as nonpathogenic microorganisms. However, some data indicate that they may be involved in the etiopathogenesis of several diseases, including intestinal diseases as well as oral(More)
nowadays, a number of antibiotic-resistant bacteria strains is increasing. it is a serious clinical problem and poses a threat to the effectiveness of conventional antibiotic therapy. thus, scientists are constantly seeking new alternatives for treatment of infectious diseases. there are some natural endogenous factors, which possess antimicrobial(More)
Nowadays, more and more data indicate that mast cells play an important role in host defense against pathogens. that is why it is essential to understand the expression of toll-like receptors (tlrs) by mast cells, because these molecules play particularly significant role in initiation host defense against microorganisms as they recognize both wide range of(More)
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