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The Sac1 lipid phosphatase dephosphorylates several phosphatidylinositol (PtdIns) phosphates and, in yeast, regulates a diverse range of cellular processes including organization of the actin cytoskeleton and secretion. We have identified mutations in the gene encoding Drosophila Sac1. sac1 mutants die as embryos with defects in dorsal closure (DC). DC(More)
Adducin is a cytoskeletal protein having regulatory roles that involve actin filaments, functions that are inhibited by phosphorylation of adducin by protein kinase C. Adducin is hyperphosphorylated in nervous system tissue in patients with the neurodegenerative disease amyotrophic lateral sclerosis, and mice lacking β-adducin have impaired synaptic(More)
We are using the maize leaf as an experimental system to ask how positional information establishes the proximal/distal axis. A mature maize leaf has three regions, the distal blade that functions in photosynthesis, the proximal sheath that wraps the stalk, and the ligule, marking a sharp boundary between blade and sheath. The recessive liguleless mutants(More)
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