Justin Metcalfe

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The mechanisms of the changes in plasma lipids concentrations observed after beta-blockade were examined in 53 patients with hypertension receiving treatment with atenolol, metoprolol, propranolol, and oxprenolol in a randomised cross-over trial. Significant increases in mean plasma total and very-low-density lipoprotein (VLDL) triglyceride and reductions(More)
Growth of the chick embryo is accelerated by brief (72-hr) exposure to 60% O2 beginning on day 16 of incubation, and acute (2-3 hr) hyperoxia stimulates oxygen consumption (VO2). However, the increment in VO2 that accompanies acute exposure to 60% O2 is only about half that required to account for the degree of growth acceleration observed during 72 hr of(More)
BACKGROUND Standard therapy for metastatic non small cell lung cancer (NSCLC) includes palliative systemic chemotherapy and/or radiotherapy. Recent studies of patients with limited metastases treated with curative-intent stereotactic body radiation therapy (SBRT) have shown encouraging survival. We hypothesized that patients treated with SBRT for limited(More)
The expiratory minute volume (Ve), respiratory frequency (f), tidal volume (VT), carbon dioxide production (Vco2), and end-tidal carbon dioxide concentration (FETCO2) and pressure (PETCO2) were measured at monthly intervals in 12 normal women during pregnancy and two, six and 12 weeks, and six months postpartum. At eacy study, measurements were made sitting(More)
Incubation of eggs in 60% oxygen has been shown to enhance growth of the chick embryo. To determine whether oxygen accelerates growth over a range of concentrations, eggs were incubated in 40% or 70% O2. Control eggs, pair-matched by initial weight, were simultaneously incubated in room air (21% O2). Embryo and organ weights from matched pairs of eggs were(More)
Serums from 4 species of deer and 1 species of antelope were analyzed for various components in order to define an animal disease model for sickle cell disease in people. Animal species included black-tailed deer (Odocoileus hemionus columbianus), mule deer (Odocoileus hemionus), sika deer (Cervus nippon nippon), fallow deer (Dama dama), and pronghorn(More)
BARTELS? HEINZ, PETER HILPERT, KLAUS BARBEY, KLAUS BETKE, KLAUS RIEGEL, ERNST MICHAEL LANG, AND JAMES METCALFE. Respiratory functions uf blood uf the yak, llama, camel, Dybowski deer, and African elephant. Am. J. Physiol. 205(2): 331-336. I963* -Blood samples from a yak, llama, camel, deer, and African elephant were analyzed for oxygen capacity, Ccstandard(More)
A six-month study of triglyceride, cholesterol, free fatty acid (FFA), glucose, insulin, growth hormone, and glucagon concentrations was carried out in asymptomatic hypertensive normal-weight men randomly allocated to treatment with atenolol or propranolol. A highly significant increase in the basal plasma triglyceride concentration was observed in(More)