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Survey of spiking in the mouse visual system reveals functional hierarchy.
TLDR
A large, open dataset that surveys spiking from tens of thousands of units in six cortical and two thalamic regions in the brains of mice responding to a battery of visual stimuli reveals that the organization of inter-area functional connectivity during visual stimulation mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas.
A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas
TLDR
A large, open dataset that surveys spiking from units in six cortical and two thalamic regions responding to a battery of visual stimuli finds that inter-area functional connectivity mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas and provides a foundation for understanding coding and dynamics in the mouse cortico-thalamic visual system.
NWB:N 2.0: An Accessible Data Standard for Neurophysiology
TLDR
This manuscript focuses in particular on the NWB:N data standard schema and present advances towards creating an accessible data standard for neurophysiology.
Characterization of Learning, Motivation, and Visual Perception in Five Transgenic Mouse Lines Expressing GCaMP in Distinct Cell Populations
TLDR
Standard methodology for training head-fixed mice on a visual change detection task is described, and the paradigm is used to characterize learning and behavior of five GCaMP6-expressing transgenic lines to map neural activity underlying perception and behavior.
cellxgene: a performant, scalable exploration platform for high dimensional sparse matrices
Quickly and flexibly exploring high-dimensional datasets, such as scRNAseq data, is underserved but critical for hypothesis generation, dataset annotation, publication, sharing, and community reuse.
Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells
TLDR
The temporal dynamics of VIP cells were stimulus-driven by novel images but were suppressed by familiar stimuli and showed ramping activity when expected stimuli were omitted from a temporally predictable sequence, suggesting that these cells may adopt different modes of processing under novel versus familiar conditions.
Targets for a Comparative Neurobiology of Language
TLDR
This work deconstructs language perception into a minimal set of cognitive processes necessary to support grammatical processing, and suggests how these mechanisms may ultimately combine to support an emergent mechanism capable of processing grammatical structures of differing complexity.
Starfish: Scalable Pipelines for Image-based Transcriptomics
The exploding field of single cell transcriptomics has begun to enable deep analysis of gene expression and cell types, but spatial context is lost in the preparation of tissue for these assays.
Experience shapes activity dynamics and stimulus coding of VIP inhibitory and excitatory cells
TLDR
Experience with natural images in a change detection task reduces overall activity of cortical excitatory and VIP inhibitory cells and suggests that VIP cells may adopt different modes of processing during familiar versus novel conditions.
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