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This paper describes the recent developments and improvements made to the variable radius niching technique called Dynamic Niche Clustering (DNC) originally described in [4] and [5]. DNC employs a separate population of overlapping fuzzy niches with independent radii which operate in the decoded parameter space and are maintained alongside the normal GA(More)
In this paper, a continuation of a variable radius niche technique called Dynamic Niche Clustering developed by (Gan & Warwick, 1999) is presented. The technique employs a separate dynamic population of overlapping niches that coexists alongside the normal population. An empirical analysis of the updated methodology on a large group of standard optimisation(More)
Granulomatosis with polyangiitis (Wegener's; GPA) is a necrotizing granulomatous vasculitis that can affect any organ system; however, central nervous system involvement is uncommon. We present 2 cases where central diabetes insipidus was the presenting manifestation of GPA. Pituitary involvement was documented by magnetic resonance imaging. Both patients(More)
Genetic algorithm’s (GA’s) have become a powerful search tool pertaining to the identification of global optima within multimodal domains. Many different methodologies and techniques have been developed to aid in this search, and facilitate the efficient location of these optima. What has become known as Goldberg’s standard fitness sharing methodology is(More)
The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to(More)
We present here some additions to a fuzzy variable radius niche technique called Dynamic Niche Clustering (DNC) [3, 4 & 5] that enable the identification and creation of niches of arbitrary shape through a mechanism called Niche Linkage. We show that by using this mechanism it is possible to attain better feature extraction from the underlying population.
Elevated chemokine receptor Ccr7 is observed in knee osteoarthritis (OA) and associated with severity of symptoms. In this study, we confirmed that CCR7 protein expression is elevated in synovial tissue from OA patients by immunohistochemical staining. We then investigated whether Ccr7 deficiency impacted structural and functional joint degeneration(More)
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