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1 Bruce CA, Rosenthal RR, Lichtenstein LM et al: Quantitative inhalation bronchial challenge in ragweed hay fever patients: A comparison with ragweed allergic asthmatics. J. Allergy Clin Immuno156:331-337,1975 2 Rosenthal RR, Newball H, Batra G, et al: Airways reactivity in allergic and nonallergic subjects. J Allergy Clin Immunol38:295,1977 3 Rosenthal RR,(More)
Water vapour partial pressure (PH2O) and temperature (T) were measured together, continuously, at the airway opening (either lips or nares) and at the oropharynx of human subjects with normal lungs or with cystic fibrosis (CF). No apparent differences in PH2O or T were found between normal and CF groups breathing ambient air (22 +/- 2 degrees C). During(More)
Exercise intolerance is common in cystic fibrosis (CF). We examined the effects of a supervised three-month running program on exercise tolerance, pulmonary function, cardiorespiratory fitness (peak oxygen consumption), and respiratory muscle endurance in CF patients. We studied 31 patients, 21 exercise and ten control, aged 10 to 30 years, with pulmonary(More)
Computation of impedances from forced oscillation data during breathing can yield results which reflect not only changes in respiratory mechanics, but artifacts related to the signal analysis. A method has been developed, employing sinusoidal forcing, to determine intra-breath variations of respiratory impedance. The measured pressure and flow waveforms are(More)
A model of chronic pulmonary infection was used for studying cellular events in a sequential manner. In this model, agarose beads containing Pseudomonas aeruginosa were instilled endotracheally into cats. Nine cats were inoculated with agarose beads containing P. aeruginosa, and four others were inoculated with sterile beads. With a fiberoptic bronchoscope,(More)
Thirty-six children and adolescents with early stages of idiopathic scoliosis underwent evaluation by echocardiography and pulmonary function testing. Mildly increased pulmonary vascular resistance was inferred from an elevated ratio of right preejection period to right ventricular ejection time, an increased right ventricular dimension, and a decreased(More)
The vapor of TDI, a chemical commonly used in the plastics industry, may be associated with pulmonary symptoms at various concentrations. Because of the high volatility and adsorptivity of TDI, it has been difficult to deliver known, dilute concentrations of TDI to test subjects in inhalation challenge studies. A delivery system has been developed which can(More)
There are limited data available supporting the use of the recombinant granulocyte colony-stimulating factor (G-CSF), tbo-filgrastim, rather than traditionally used filgrastim to mobilize peripheral blood stem cells (PBSC) or to accelerate engraftment after autologous stem cell transplantation (ASCT). We sought to compare the efficacy and cost of(More)
Quantitative characteristics of the dynamic mechanical and gas distribution behavior in 6 normal subjects and 5 subjects with COPD were compared during tidal breathing. Transpulmonary pressure, total lung volume, flow, and N2 fraction at the mouth were measured while N2 was washed out from the lung. The washouts were performed at several frequencies and(More)