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We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell. This method is based on the construction of a three-dimensional digital model cell from confocal microscopy data. The model cell is segmented into the cytoplasm, nucleus, plasma membrane, and nuclear envelope, in which environment protein motion is modeled by fully(More)
BACKGROUND Obesity and osteoporosis, two possibly related conditions, are rapidly expanding health concerns in modern society. Both of them are associated with sedentary life style and nutrition. To investigate the effects of diet-induced obesity and voluntary physical activity we used high resolution micro-computed tomography (μCT) together with peripheral(More)
  • A V Rybin, G G Varzugin, M Lindberg, J Timonen, R K Bullough
  • 2008
We analyse a generalised Gross-Pitaevskii equation involving a paraboloidal trap potential in D space dimensions and generalised to a nonlinearity of order 2n + 1. For attractive coupling constants collapse of the particle density occurs for Dn ≥ 2 and typically to a δ-function centered at the origin of the trap. By introducing a new dy-namical variable for(More)
Although carbon nanotubes consist of honeycomb carbon, they have never been fabricated from graphene directly. Here, it is shown by quantum molecular-dynamics simulations and classical continuum-elasticity modeling, that graphene nanoribbons can, indeed, be transformed into carbon nanotubes by means of twisting. The chiralities of the tubes thus fabricated(More)
Results of experiments on the dynamics and kinetic roughening of one-dimensional slow-combustion fronts in three grades of paper are reported. Extensive averaging of the data allows a detailed analysis of the spatial and temporal development of the interface fluctuations. The asymptotic scaling properties, on long length and time scales, are well described(More)
Crumpling a thin sheet of material into a small volume requires energy for creating a network of deformations such as vertices and ridges. Scaling properties of a single elastic vertex or ridge have been analysed theoretically, and crumpling of a sheet by numerical simulations. Real materials are however elasto-plastic and large local strains induce(More)
The nucleus of interphase eukaryotic cell is a highly compartmentalized structure containing the three-dimensional network of chromatin and numerous proteinaceous subcompartments. DNA viruses induce profound changes in the intranuclear structures of their host cells. We are applying a combination of confocal imaging including photobleaching microscopy and(More)
In the early stages of running of the CRESST dark matter search using sapphire detectors at very low temperature, an unexpectedly high rate of signal pulses appeared. Their origin was finally traced to fracture events in the sapphire due to the very tight clamping of the detectors. During extensive runs the energy and time of each event was recorded,(More)
  • Urpo Aaltosalmi, Rudolf Hilfer, Rune Holmstad, Christian Manwart, Shri Ra-Maswamy, Mr Marko Rasi +21 others
  • 2005
Preface The work reviewed in this thesis has been carried out during the years 1999-2004 in the Department of Physics at the University of Jyväskylä. First I would like to thank my supervisors Professor Jussi Timonen, Professor Markku Kataja and Docent Antti Koponen for their invaluable contributions during the preparation of the enclosed articles and this(More)
Three dimensional (3-D) magnetic resonance (MR) microimaging combined with connectivity analysis was tested in the study of the structure of cancellous bone. MR microimaging was performed in vitro with an average resolution of 20*20*35 microm. A 3-D connectivity analysis was used to model the trabecular bone as a network consisting of nodes and struts. Size(More)