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We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell. This method is based on the construction of a three-dimensional digital model cell from confocal microscopy data. The model cell is segmented into the cytoplasm, nucleus, plasma membrane, and nuclear envelope, in which environment protein motion is modeled by fully(More)
BACKGROUND Obesity and osteoporosis, two possibly related conditions, are rapidly expanding health concerns in modern society. Both of them are associated with sedentary life style and nutrition. To investigate the effects of diet-induced obesity and voluntary physical activity we used high resolution micro-computed tomography (μCT) together with peripheral(More)
Stochastic driven flow along a channel can be modeled by the asymmetric simple exclusion process. We confirm numerically the presence of a dynamic queuing phase transition at a nonzero obstruction strength, and establish its scaling properties. Below the transition, the traffic jam is macroscopic in the sense that the length of the queue scales linearly(More)
Simplicity of coding is usually an appealing feature of the lattice-Boltzmann method (LBM). Conventional implementations of LBM are often based on the two-lattice or the two-step algorithm, which however suffer from high memory consumption and poor computational performance, respectively. The aim of this work was to identify implementations of LBM that(More)
Preface The work reviewed in this thesis has been carried out during the years 1999-2004 in the Department of Physics at the University of Jyväskylä. First I would like to thank my supervisors Professor Jussi Timonen, Professor Markku Kataja and Docent Antti Koponen for their invaluable contributions during the preparation of the enclosed articles and this(More)
Crumpling a thin sheet of material into a small volume requires energy for creating a network of deformations such as vertices and ridges. Scaling properties of a single elastic vertex or ridge have been analysed theoretically, and crumpling of a sheet by numerical simulations. Real materials are however elasto-plastic and large local strains induce(More)
Results of experiments on the dynamics and kinetic roughening of one-dimensional slow-combustion fronts in three grades of paper are reported. Extensive averaging of the data allows a detailed analysis of the spatial and temporal development of the interface fluctuations. The asymptotic scaling properties, on long length and time scales, are well described(More)
In the early stages of running of the CRESST dark matter search using sapphire detectors at very low temperature, an unexpectedly high rate of signal pulses appeared. Their origin was finally traced to fracture events in the sapphire due to the very tight clamping of the detectors. During extensive runs the energy and time of each event was recorded,(More)