Jurandy Susana Patrícia Ocampo

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Thymocyte differentiation occurs within the thymic microenvironment, consisting of distinct cell types and extracellular matrix (ECM) elements. One of these ECM proteins is laminin. Previous experiments showed that laminin mediates interactions between thymocytes and thymic epithelial cells (TEC) in mice. Since, laminin comprises a family of related(More)
Cell migration is a crucial event in the general process of thymocyte differentiation. The cellular interactions involved in the control of this migration are beginning to be defined. At least chemokines and extracellular matrix proteins appear to be part of the game. Cells of the thymic microenvironment produce these two groups of molecules, whereas(More)
Thymocyte differentiation is the process by which bone marrow-derived precursors enter the thymus, proliferate, rearrange the genes and express the corresponding T cell receptors, and undergo positive and/or negative selection, ultimately yielding mature T cells that will represent the so-called T cell repertoire. This process occurs in the context of cell(More)
Due to the great genetic diversity of HIV, producing an effective vaccine is extremely difficult. The combined antiretroviral therapy, although not leading to a cure, is capable of preventing opportunistic infections, since it greatly reduces HIV viral load in the blood. Considering a large number of HIV infections occur through sexual intercourse, the use(More)
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