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OBJECTIVE To evaluate the GP6 gene polymorphism in patients with sticky platelet syndrome (SPS) and fetal loss. DESIGN Genetic association study. SETTING Perinatal center. PATIENT(S) Twenty-seven patients with SPS, manifested as fetal loss, and 42 control subjects without SPS and no history of fetal loss and thrombosis. INTERVENTION(S) SPS was(More)
INTRODUCTION The aim of this study was to evaluate the genetic variability of selected single nucleotide polymorphisms (SNPs) within GAS6 and PEAR1 genes and explore the association between selected SNPs and risk for fetal loss in women with sticky platelet syndrome (SPS). MATERIALS AND METHODS We examined 23 female patients with SPS and history of(More)
INTRODUCTION Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers--adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence. MATERIAL AND METHODS Familial trait of SPS was looked up in the database of the(More)
INTRODUCTION Thrombophilia increases the risk of venous thrombosis during pregnancy and may predispose to gestational vascular complications. OBJECTIVE The aim of this study is to evaluate the variability of GP6 regulatory regions in a group of patients with platelet hyperaggregability manifested as miscarriage compared with control subjects. METHODS We(More)
PATIENT Female, 51. FINAL DIAGNOSIS Sticky platelets syndrome. SYMPTOMS Pulmonary embolism. MEDICATION - CLINICAL PROCEDURE Thrombolysis. SPECIALTY Hematology. OBJECTIVE Disease of unknown ethiology. BACKGROUND Sticky platelets syndrome (SPS) is an inherited thrombophilia characterized by platelet hyperaggregability, which can lead to the(More)