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The safety and efficacy of gene therapy for inherited retinal diseases is being tested in humans affected with Leber's congenital amaurosis (LCA), an autosomal recessive blinding disease. Three independent studies have provided evidence that the subretinal administration of adeno-associated viral (AAV) vectors encoding RPE65 in patients affected with LCA2(More)
An artificial microbial community consisted of Ketogulonicigenium vulgare and Bacillus megaterium has been used in industry to produce 2-keto-gulonic acid (2-KGA), the precursor of vitamin C. During the mix culture fermentation process, sporulation and cell lysis of B. megaterium can be observed. In order to investigate how these phenomena correlate with(More)
OBJECTIVE To investigate the efficacy and safety of regional intra-arterial chemotherapy (RIAC) versus systemic chemotherapy for stage III/IV pancreatic cancer. METHODS Randomized controlled trials of patients with advanced pancreatic cancer treated by regional intra-arterial or systemic chemotherapy were identified using PubMed, ISI, EMBASE, Cochrane(More)
Heavy metals are regarded as toxic trace elements in the environment. Heavy metal pollution in soil or rice grains is of increasing concern. In this study, 101 pairs of soil and rice samples were collected from the major rice-producing areas along the Yangtze River in China. The soil properties and heavy metal (i.e., Cd, Hg, Pb and Cr) concentrations in the(More)
In this paper, based on the knowledge of memristor and recurrent neural networks (RNNs), the model of the memristor-based RNNs with discrete and distributed delays is established. By constructing proper Lyapunov functionals and using inequality technique, several sufficient conditions are given to ensure the passivity of the memristor-based RNNs with(More)