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OBJECTIVE To demonstrate whether leptin modulates reproduction by a direct effect within the ovary. DESIGN Animal model. SETTING National Key Laboratory of Infertility. ANIMAL(S) Adult female db/db mice. INTERVENTION(S) Adult littermate wild-type (WT) and diabetic (db) leptin receptor (LR) mutant female mice were matched for the allograft of the(More)
PURPOSE The capacity of nadir CA-125 levels to predict the prognosis of epithelial ovarian cancer remains controversial. This study aimed to explore whether the nadir CA-125 serum levels could predict the durations of overall survival (OS) and progression free survival (PFS) in patients with high-grade serous ovarian cancer (HG-SOC) from the USA and PRC. (More)
BACKGROUND There is no consensus regarding the secondary cytoreduction surgery (CRS) in recurrent ovarian cancer patients. The present study aims to determine the value of secondary CRS and the eligible subgroup for this procedure. METHODS 96 platinum-sensitive recurrent ovarian cancer patients were recruited from Jiangsu Institute of Cancer Research(More)
OBJECTIVE To investigate whether insulin resistance (IR) within theca cells may directly contribute to their hyperandrogenism, a heritable trait of polycystic ovary syndrome (PCOS). DESIGN In vitro cell model. SETTING University-affiliated laboratory. ANIMAL(S) Porcine ovaries. INTERVENTION(S) Ovarian theca cells from porcine follicles were isolated(More)
In traditional Chinese medicine, polycystic ovary syndrome (PCOS) is considered an anovulation disorder related to ovarian insulin resistance. The three phenotypes of PCOS, according to the Rotterdam criteria, are differently steroidogenic but similarly insulin resistant, suggesting a similar involvement of insulin resistance/hyperinsulinemia in different(More)
BACKGROUND Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis.(More)
BACKGROUND This research investigated the response of vascular active factors, vascular endothelial growth factor (VEGF) and angiotensin-II (AT-II) to ovarian stimulation during 24 hours in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS In this clinical trial study, 52 patients with PCOS and 8 control cases were stimulated with(More)
OBJECTIVE The purpose of this study was to build a video endoscopic inguinal lymphadenectomy (VEIL) via the 3-incision superolateral inguinal approach and explore the feasibility and significance of this method for vulvar cancer. METHODS Thirty-seven patients with vulvar cancer who underwent VEIL via the 3-incision superolateral inguinal approach were(More)
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