Junping Zhan

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Similar symptoms of the different types of arthritis have continued to confound the clinical diagnosis and represent a clinical dilemma making treatment choices with a more personalized or generalized approach. Here we report a mass spectrometry-based metabolic phenotyping study to identify the global metabolic defects associated with arthritis as well as(More)
ETHNOPHARMACOLOGICAL RELEVANCE Chinese herbal medicines (HMs) is one of the great herbal systems of the world, which play an important role in current health care system in many countries. In the view of tradition Chinese medicine (TCM) theory, Yin-yang and five-elements theory is the central theory, which is used to explain how the world and body work.(More)
Diabetes mellitus, or simply diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. In traditional Chinese medicine (TCM), diabetes mellitus is called “Sweet Urine Disease”. Over several thousand(More)
It is an interesting and meaningful thing to explore the associated networks between cold herb and hot herb within the framework of traditional Chinese medicine because they might be useful for both clinical practice and scientific research. In this study, focused on the fields of disease, pattern/syndrome, symptom, and decoction, we constructed the(More)
The hyperplastic growth of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) and inflammatory response are pathological hallmarks of RA. It has been reported that Astragalus polysaccharides (APS) possess appreciable anti-inflammatory activity against adjuvant-induced arthritis. Nevertheless, little is known about the role and detailed mechanism(More)
This study is aiming to develop a novel pattern recognition approach for identifying the cold and hot properties of Chinese medicinal herbs. All associated target proteins in the herbs with different properties were obtained from PubChem and other public databases, and the pattern recognition algorithms were used to analyze the proteins coupled with pathway(More)