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— The message passing approach to model-based signal processing is developed with a focus on Gaussian message passing in linear state space models, which includes recursive least squares, linear minimum-mean-squared-error estimation, and Kalman filtering algorithms. Tabulated message computation rules for the building blocks of linear models allow to(More)
A systematic survey of heavy metal (HM) concentrations and bioaccessibilities in market vegetables in Hong Kong were carried out for assessing potential health risk to local inhabitants. The average concentrations of Cd, Pb, Cr, Ni, Cu, and Zn in nine major groups of fresh vegetable varied within 0.007-0.053, 0.05-0.17, 0.05-0.24, 0.26-1.1, 0.62-3.0, and(More)
A paclitaxel/MPEG-PLA block copolymer conjugate was prepared in three steps: (1) hydroxyl-terminated diblock copolymer of monomethoxy-poly(ethylene glycol)-b-poly(lactide) (MPEG-PLA) was synthesized by ring-opening polymerization of L-lactide using MPEG as a maroinitiator; (2) it was converted to carboxyl-terminated MPEG-PLA by reacting with mono-t-butyl(More)
Injectable cartilaginous constructs that can form gels in tissue defects have many advantages in tissue engineering applications. In this study we created an injectable hydrogel consisting of methacrylated glycol chitosan (MeGC) and hyaluronic acid (HA) by photocrosslinking with a riboflavin photoinitiator under visible light. A minimum irradiation time of(More)
Chitosan/tripolyphosphate/chondroitin sulfate (Chi/TPP/CS) nanoparticles were prepared by an ionic gelation method to obtain a controlled release of proteins. Using Nel-like molecule-1 (Nell-1), a novel osteogenic protein, as a model protein, it was demonstrated that adjusting the composition of the particles modulated the protein association and release(More)
The effects of mineral fertilizer (NPK) and organic manure on the community structure of soil ammonia-oxidizing bacteria (AOB) was investigated in a long-term (16-year) fertilizer experiment. The experiment included seven treatments: organic manure, half organic manure N plus half fertilizer N, fertilizer NPK, fertilizer NP, fertilizer NK, fertilizer PK,(More)
— Elaborating on prior work by Minka, we formulate a general computation rule for lossy messages. An important special case (with many applications in communications) is the conversion of " soft-bit " messages to Gaussian messages. By this method, the performance of a Kalman equalizer is improved, both for uncoded and coded transmission.
Site-specific PEGylation offers the possibility to modify a therapeutic protein without interfering with its biological activity. Previously, a preferential N-terminal PEGylation has been reported for several proteins when the reaction was performed at acidic pH. In the present study it was explored if acidic pH favors N-terminal PEGylation of bone(More)
Three cysteine analogues of bone morphogenetic protein (BMP)-2, BMP2A2C, BMP2N56C, and BMP2E96C, were generated in order to enable the attachment of SH-reactive poly(ethylene glycol) (PEG) at specific sites. Three different approaches (Ap) were used for SH-specific PEGylation: (Ap1) reaction of glutathione activated proteins with thiol PEG; (Ap2) reaction(More)