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Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells
TLDR
Oleuropein or hydroxytyrosol, major phenolic compound of olive oil, was studied for its effects on growth in MCF-7 human breast cancer cells using assays for proliferation, cell viability, inhibited cell proliferation, and induced cell apoptosis.
Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2.
TLDR
R. officinalis' CA and RA exhibited neurotrophic effects in PC12 cells through cell differentiation induction and cholinergic activities enhancement, which could be regulated by mitogen-activated protein kinase (MAPK), ERK1/2 signaling pathway.
Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside
TLDR
The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.
Inhibitory Effect of Fulvic Acid Extracted from Canadian Sphagnum Peat on Chemical Mediator Release by RBL-2H3 and KU812 Cells
TLDR
The results show that CP-FA may be useful for the treatment or prevention of allergic diseases and inhibited histamine release from A23187 plus PMA- or compound 48/80-stimulated KU812 cells.
Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.
TLDR
The analysis of the relationship between the structure and function of the flavonoids suggest that the apigenin-induced K562 cell differentiation was due to the 2-3 double bond and hydroxyl groups in its structure.
Properties of Fulvic Acid Extracted from Excess Sludge and Its Inhibiting Effect on β-Hexosaminidase Release
TLDR
The physicochemical and biological properties of fulvic acid extracted and purified from excess sludge and solubilization showed an inhibitory effect on β-hexosaminidase release at the antigen-antibody binding stage and antigen-receptor binding stage by using rat basophilic leukemia cells.
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.
TLDR
Examination of the anti-amyloidogenic property of CQA-related compounds for AD therapy indicates that 3,4,5-tri-CQA could be a potential agent for the prevention of AD.
In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification
TLDR
Data suggest that A. indicum could be a promising candidate species as a source of anticancer molecules because of its interesting antioxidant capacities associated with a significant antiproliferative effect explained by a cell cycle blocking at the G2/M phase.
Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells
TLDR
It is reported here that Tunisian C. spinosa leaf extract can stimulate melanogenesis in a dose-dependent manner without cytotoxicity by increasing tyrosinase protein expression and has the potential to be used as a possible tanning agent or as a treatment for hair depigmentation.
Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation
TLDR
First evidence to contribute to the understanding of molecular mechanism behind the anti-depressant effect of R. officinalis is contributed, with results concordant with decreasing immobility time in TST and regulation of several neurotransmitters and gene expression in mice brain.
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