Junko Nakamura

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BACKGROUND KRAS, BRAF and PIK3CA mutations are frequently observed in colorectal cancer (CRC). In particular, KRAS mutations are strong predictors for clinical outcomes of EGFR-targeted treatments such as cetuximab and panitumumab in metastatic colorectal cancer (mCRC). For mutation analysis, the current methods are time-consuming, and not readily available(More)
Calreticulin 3 (CALR3) is considered a candidate gene in human male infertility because male, but not female, CALR3-deficient mice are infertile. To investigate the possible association between variations in CALR3 and impaired spermatogenesis in humans, we screened for mutations in human CALR3 using DNA from 892 infertile male patients and 167(More)
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