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Composition of Perineuronal Net Extracellular Matrix in Rat Brain
We developed a method to extract differentially chondroitin sulfate proteoglycans (CSPGs) that are diffusely present in the central nervous system (CNS) matrix and CSPGs that are present in the
Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist,
TLDR
FTIDC is a highly potent and selective allosteric mGluR1 antagonist and a compound having oral activity without species differences in its antagonistic activity on recombinant human, mouse, and rat mGlamR1 and could be a valuable tool for elucidating the functions of mGLUR1 not only in rodents but also in humans.
Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum
TLDR
The results suggest that the IdoUA-containing iA and iB units along with D/iD and E/iE units in the CS/DS hybrid play important roles in the formation of the cerebellar neural network during postnatal brain development.
Functions of Chondroitin Sulfate/Dermatan Sulfate Chains in Brain Development
TLDR
Investigation of the specificity of GD3G7 toward various glycosaminoglycan preparations showed that this antibody specifically reacted with squid CS-E, hagfish CS-H, and shark skin DS, suggesting that the epitope is embedded in the neurite outgrowth-promoting motif ofCS-E.
Marked increase of serum hepatitis C virus (HCV) RNA titer during treatment with high-dose prednisolone in a case of polymyositis
TLDR
Although intensive immunosuppression is necessary as an initial treatment of several collagen diseases including polymyositis, high-dose PSL therapy may markedly augment the serum HCV RNA level and therefore careful observation is necessary in HCV-infected patients.
Comparison of antibody response following the second dose of SARS-CoV-2 mRNA vaccine in elderly patients with late-stage chronic kidney disease
TLDR
In elderly patients with late-stage CKD, antibody titers tended to be lower in the G5D group than in theG4 and G5 groups despite the shorter time since vaccination; therefore, CKD stage progression might cause a decline in antibody titer levels.