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NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.
The BH3-only protein NBK/BIK is the apical regulator of a BAK-dependent apoptotic pathway in response to shutoff of protein synthesis that functions to displace BAK from sequestration by MCL1 and BCL-X(L). Expand
Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells.
Bacterial lipopolysaccharide induces ATX expression in THP-1 cells via a PKR, JNK and p38 MAPK-mediated mechanism, and the ATX induction is likely to enhance immune cell migration in proinflammatory response by regulating LPA levels in the microenvironment. Expand
Plasma choline-containing phospholipids: potential biomarkers for colorectal cancer progression
Colorectal cancer (CRC) is believed to progress through the adenoma–carcinoma sequence. The adenoma–carcinoma transition is an important window for early detection and intervention of CRC. In theExpand
Isolation of α-glucosidase inhibitors including a new flavonol glycoside from Dendrobium devonianum
From the whole plant of Dendrobium devonianum, a new flavonol glycoside, 5-hydroxy-3-methoxy-flavone-7-O-[β-d-apiosyl-(1 → 6)]-β- d-glucoside, as well as 13 known compounds, was isolated and both displayed more potent α- glucosidase inhibitory activity than acarbose. Expand
Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition
Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition, indicating that tumor protein 53 (TP53) is essential for the autophagy induction. Expand
Biochemical characterization of a chromosomal toxin–antitoxin system in Mycobacterium tuberculosis
Both Rv1991a and the Rv 1991a–Rv1991c complex were able to bind to the promoter region of the R v1991a-Rv 1991c operon, indicating that the expression of the H2O–H2O/ORF pair can be autoregulated. Expand
ATX and LPA receptor 3 are coordinately up‐regulated in lipopolysaccharide‐stimulated THP‐1 cells through PKR and SPK1‐mediated pathways
It is found that ATX and LPA receptor 3 (LPA3) are coordinately up‐regulated in LPS‐stimulated THP‐1 cells, suggesting that ATx and L PA3 are involved in CCL8 induction during the inflammatory process against bacterial infection. Expand
A trigger model of apoptosis induced by tumor necrosis factor signaling
The results suggest that bistability may not be a necessary condition for the induction of apoptosis by TNF signaling, and a sharp increase in caspase-3 activity might be sufficient to trigger the inductionof an irreversible death program. Expand
Experimental Investigation of the Aerodynamic Roughness Length for Flexible Plants
The aerodynamic roughness length z0 is modelled as a function of the zero-plane displacement d, plant drag coefficient CdR, the ratio β of the drag coefficient for an isolated roughness element andExpand
A new sesquiterpenoid from Polyalthia petelotii
The isolates were assessed for their cytotoxicity against five human tumour lines, and the result showed that only 2 displayed weak inhibitory activity. Expand