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Reduced expression of miR-129 has been reported in multiple tumor cell lines and in primary tumors including medulloblastoma, undifferentiated gastric cancers, lung adenocarcinoma, endometrial cancer and colorectal carcinoma. There is also recent evidence of an anti-proliferative activity of miR-129 in tumor cell lines. Still, little is known about how(More)
Clustering validation has long been recognized as one of the vital issues essential to the success of clustering applications. In general, clustering validation can be categorized into two classes, external clustering validation and internal clustering validation. In this paper, we focus on internal clustering validation and present a detailed study of 11(More)
Recent years have witnessed the explosive growth of online social media. Weibo, a Twitter-like online social network in China, has attracted more than 300 million users in less than three years, with more than 1000 tweets generated in every second. These tweets not only convey the factual information, but also reflect the emotional states of the authors,(More)
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong.(More)
MicroRNAs (miRNA) are small regulatory RNAs that control gene expression by translational suppression and destabilization of target mRNAs. There is increasing evidence that miRNAs regulate genes associated with fibrosis in organs, such as the heart, kidney, liver, and the lung. In a large-scale screening for miRNAs potentially involved in bleomycin-induced(More)
K-means is a widely used partitional clustering method. While there are considerable research efforts to characterize the key features of K-means clustering, further investigation is needed to reveal whether and how the data distributions can have the impact on the performance of K-means clustering. Indeed, in this paper, we revisit the K-means clustering(More)
Recently, there has been an explosive growth in Internet services, greatly increasing the importance of data center systems. Applications served from “the cloud” are driving data center growth and quickly overtaking traditional workstations. Although there are a many tools for evaluating components of desktop and server architectures in(More)