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RATIONALE AND OBJECTIVES A computerized scheme for automated detection of lung nodules in low-dose computed tomography images for lung cancer screening was developed. MATERIALS AND METHODS Our scheme is based on a difference-image technique for enhancing the lung nodules and suppressing the majority of background normal structures. The difference image(More)
RATIONALE AND OBJECTIVE We developed a technique that uses a multiple massive-training artificial neural network (multi-MTANN) to reduce the number of false-positive results in a computer-aided diagnostic (CAD) scheme for detecting nodules in chest radiographs. MATERIALS AND METHODS Our database consisted of 91 solitary pulmonary nodules, including 64(More)
We investigated a psychophysical similarity measure for selection of images similar to those of unknown masses on mammograms, which may assist radiologists in the distinction between benign and malignant masses. Sixty pairs of masses were selected from 1445 mass images prepared for this study, which were obtained from the Digital Database for Screening(More)
Presentation of images of lesions similar to that of an unknown lesion might be useful to radiologists in distinguishing between benign and malignant clustered microcalcifications on mammograms. Investigators have been developing computerized schemes to select similar images from large databases. However, whether selected images are really similar in(More)
We developed an advanced computer-aided diagnostic (CAD) scheme for the detection of various types of lung nodules on chest radiographs intended for implementation in clinical situations. We used 924 digitized chest images (992 noncalcified nodules) which had a 500 x 500 matrix size with a 1024 gray scale. The images were divided randomly into two sets(More)
The purpose of this study was to investigate four objective similarity measures as an image retrieval tool for selecting lesions similar to unknown lesions on mammograms. Measures A and B were based on the Euclidean distance in feature space and the psychophysical similarity measure, respectively. Measure C was the sequential combination of B and A, whereas(More)
OBJECTIVE The purpose of our study was to evaluate whether a computer-aided diagnosis (CAD) scheme can assist radiologists in distinguishing small benign from malignant lung nodules on high-resolution CT (HRCT). MATERIALS AND METHODS We developed an automated computerized scheme for determining the likelihood of malignancy of lung nodules on multiple HRCT(More)
The presentation of images with lesions of known pathology that are similar to an unknown lesion may be helpful to radiologists in the diagnosis of challenging cases for improving the diagnostic accuracy and also for reducing variation among different radiologists. The authors have been developing a computerized scheme for automatically selecting similar(More)
The presentation of images that are similar to that of an unknown lesion seen on a mammogram may be helpful for radiologists to correctly diagnose that lesion. For similar images to be useful, they must be quite similar from the radiologists' point of view. We have been trying to quantify the radiologists' impression of similarity for pairs of lesions and(More)
Computer-aided diagnosis (CAD) provides a computerized diagnostic result as a " second opinion " to assist radiologists in the diagnosis of various diseases by use of medical images. CAD has become a practical clinical approach in diagnostic radiology, although, at present, primarily in the area of detection of breast cancer in mammograms. Currently, a(More)