Junji Komatsu

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Purpose. Although defecatory function after low anterior resection for rectal cancer is reported to be better following colonic J-pouch than straight anastomosis, few prospective randomized trials comparing the two forms of anastomosis have been reported. We performed a prospective randomized trial comparing straight anastomosis with colonic J-pouch(More)
Purpose. Patients who have undergone low anterior resection (LAR) of the rectum occasionally complain of symptoms related to impaired neorectal evacuation. Using scintigraphy, we assessed neorectal evacuation in 22 patients who underwent LAR and straight anastomosis, and correlated the results with clinical defecatory function, clinical factors, and(More)
A semi-closed hemorrhoidectomy is a popular surgical procedure among Japanese coloproctologists because it is thought that the risk of postoperative bleeding is reduced, and postoperative pain is milder after a semi-closed hemorrhoidectomy than after an open hemorrhoidectomy. However, no prospective randomized trial comparing an open and semi-closed(More)
Purpose. We investigated intersphincteric resection with hand-sewn coloanal anastomosis, which may be an alternative to standard low anterior resection for very low rectal cancer when stapled anastomosis is technically impossible. Methods. The present study compared the clinical and functional results of 16 patients who underwent stapled colonic J-pouch(More)
To determine the influence of anal canal sensation on anal function after low anterior resection (LAR) for rectal cancer, anal canal sensation was quantitatively evaluated before and after LAR by measuring anal mucosal electrosensitivity (AMES), and the relationship between AMES and postoperative anal function was explored. Sensory thresholds 1, 2, and 3 cm(More)
We report a Japanese patient with Creutzfeldt-Jakob disease (CJD) with a V203I homozygous mutation of the prion protein gene (PRNP). A 73-year-old woman developed rapidly progressive gait disturbance and cognitive dysfunction. Four months after the onset, she entered a state of an akinetic mutism. Gene analysis revealed a homozygous V203I mutation in the(More)
OBJECTIVE To evaluate the long-term efficacy and safety of diflunisal in late-onset familial amyloid polyneuropathy (FAP) in a Japanese endemic area. METHODS Consecutive six FAP patients (mean age: 65.8 ± 7.3 years) with a transthyretin (TTR) Val30Met mutation from an endemic area of late-onset FAP were prospectively recruited to an open label study with(More)
BACKGROUND Alzheimer's disease (AD) commonly accompanies cerebral amyloid angiopathy (CAA). OBJECTIVE We aimed to reveal associations between CAA-related brain microbleeds and cerebrospinal fluid (CSF) markers in AD patients. METHODS Patients with probable AD (n = 88) from consecutive patients in our memory clinic were evaluated for patient(More)
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We report the case of a 50-year-old man who presented with progressive gait ataxia. Brain magnetic resonance imaging (MRI) on fluid-attenuated inversion recovery revealed a hyperintense lesion in the right temporal white matter. The spinal cord showed a long(More)
pairment progressing during 1 year. His two brothers and one sister had dementia. Except for memory impairment, he had no abnormal neurological findings. Brain MRI showed mild frontotemporal atrophy involving hippocampus (Fig. 1). Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) revealed marked hypometabolism in the temporal poles as(More)
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