Junichi Takahashi

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PPARgamma agonists, thiazolidinediones, cause fluid retention and edema due to unknown mechanisms. We characterized the effect of rosiglitazone (RSG), a thiazolidinedione, to induce vascular permeability, vascular endothelial growth factor (VEGF) expression, and protein kinase C (PKC) activation with edema and wt gain. In lean, fatty and diabetic Zucker(More)
Increases in leukostasis/monocyte adhesion to the capillary endothelium (leukostasis) and decreases in retinal blood flow may be causally associated and are implicated in the pathogenesis of diabetic retinopathy. In this study, we demonstrate that increases in leukostasis are observed in insulin-resistant states without diabetes, whereas decreases in(More)
A 48-year-old man was admitted because of severe dyspnea. The patient was in a healthy condition until one week before, when he noticed dyspnea on exertion. He had a history of thyroid papillary adenocarcinoma for which he had undergone right thyroid lobectomy 10 years ago. After that, tumorectomy for local recurrence has been performed for three times. On(More)
The adsorption and infection of bacteriophage P2 is mediated by tail fibres and tail spikes. The tail spikes on the tail baseplate are used to irreversibly adsorb to the host cells. Recently, a P2 phage tail-spike protein, gpV, was purified and it was shown that a C-terminal domain, Ser87-Leu211, is sufficient for the binding of gpV to host Escherichia coli(More)
To evaluate quantitatively the effects of bucillamine on the entrapment of leukocytes in the retinal microcirculation of diabetic rats. 13 male Brown Norway rats were injected with streptozotocin (STZ). After the animals developed diabetes, they were divided into two groups. Group 1 (n = 7) received fresh drinking water without bucillamine, and group 2 (n =(More)
We present a case of metastatic pulmonary calcification. Histologically, deposition of hematoxyphilic materials was seen along the alveolar and vessel walls. Fibrous tissues were also seen within the alveolar lumens, resulting in intra-alveolar fibrous pneumonia. Immunohistochemically, CD34-positive perivascular adventitial fibroblasts were seen in normal(More)
To measure choroidal thickness in healthy pregnant women using enhanced depth imaging optical coherence tomography (EDI-OCT) and compare the measurements with those of healthy non-pregnant women. Choroidal thickness was measured at the fovea and at 3 mm superior, inferior, temporal, and nasal to the fovea using EDI-OCT in both healthy pregnant and(More)
A case of unilateral horizontal gaze palsy is reported. The lesion of the abducens nucleus was clearly detected with magnetic resonance imaging. In the early stage, the adduction of the right eye and abduction of the left eye were completely limited and the vestibulo-ocular reflex was also impaired. However, during the recovery stage, the improvement of(More)
BACKGROUND To evaluate the effect of nucleotide P2Y(2) receptor agonists INS542 and uridine 5'-triphosphate (UTP) on the outward active transport of fluorescein across rabbit blood-retina barrier (BRB) in vivo. METHODS Injection (0.1 ml) of INS542 (0.1 or 1mM), phosphate buffered solution, or UTP (1 or 10mM) was made in Dutch-belted rabbits. Differential(More)