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Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 (AMPKα2) in adipocytes, which in turn(More)
Recent global climate changes have affected vegetation coverage in the Tibetan Plateau. Based on the remote sensing images and the meteorological data from 1986 to 2000, using the model of extracting vegetation coverage, the spatiotemporal changes of vegetation coverage and its responses to global climate changes in the Tibetan Plateau during 1986-2000 were(More)
The current study investigated how between-subject and within-subject variance-covariance structures affected the detection of a finite mixture of unobserved subpopulations and parameter recovery of growth mixture models in the context of linear mixed-effects models. A simulation study was conducted to evaluate the impact of variance-covariance structure(More)
A central challenge in using learning progressions (LPs) in practice is modeling the relationships that link student performance on assessment tasks to students' levels on the LP. On the one hand, there is a progression of theoretically defined levels, each defined by a configuration of knowledge, skills, and/or abilities (KSAs). On the other hand, there(More)
The findings and opinions expressed in this report are those of the authors and do not necessarily reflect the positions or policies of the Center for Advance Technology in Schools Abstract A major issue in the study of learning progressions (LPs) is linking student performance on assessment tasks to the progressions. This report describes the challenges(More)
This paper studies the design of data fusion algorithm for asynchronous system with integer times sampling. Firstly, the multisensor asynchronous samplings is mapped to the basic axis, accordingly a sampling sequence of single sensor can be taken. Secondly, aiming at the sensor with the densest sampling points, the modified parallel filtering is given.(More)
Inversion of aerosol optical depth (AOD) over bright land surface by optical remote sensing is particularly challenging because surface reflectance dominates the satellite signal. A structure function method is suitable and can effectively solve aerosol optical depth inversion in high reflectance areas. How to select d (the pixel distance between two(More)
Objective: Case reports and retrospective review of remote cerebellar hemorrhage after microsurgical clipping of intracranial aneurysms. Methods: The medical and pathologic records were reviewed of 13 patients with remote cerebellar hemorrhage occurred after microsurgical clipping of intracranial aneurysms procedure during 2013-2014. Clinical symptoms,(More)
A Monte Carlo simulation is employed to investigate the performance of five estimation methods of nonlinear mixed effects models in terms of parameter recovery and efficiency of both regression coefficients and variance/covariance parameters under varying levels of data sparseness and model misspecification.
How stiffness and strength of the human lumbar endplate vary with location, spinal level, and its correlation with MRI findings of lumbar degeneration, has not been reported in detail. 27 lumbar spines (16 male, 11 female, 31-49yrs) were harvested from cadavers without history of lumbar lesion or trauma. Disc and endplate degeneration was evaluated from(More)