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Active migration and invasion by cancer cells are a prerequisite for the development of metastases. Recent studies have shown that neurotransmitters are involved in the regulation of cancer cell invasion via beta-adrenoceptors (beta-ARs). However, little is known regarding the effect of neurotransmitters on pancreatic cancer cells. The aim of our study was(More)
Incorporating semantic structure into a linguistics-free translation model is challenging, since semantic structures are closely tied to syntax. In this paper, we propose a two-level approach to exploiting predicate-argument structure reordering in a hierarchical phrase-based translation model. First, we introduce linguistically motivated constraints into a(More)
This paper explores Chinese semantic role labeling (SRL) for nominal predicates. Besides those widely used features in verbal SRL, various nominal SRL-specific features are first included. Then, we improve the performance of nominal SRL by integrating useful features derived from a state-of-the-art verbal SRL system. Finally, we address the issue of(More)
Chiang’s hierarchical phrase-based (HPB) translation model advances the state-of-the-art in statistical machine translation by expanding conventional phrases to hierarchical phrases – phrases that contain sub-phrases. However, the original HPB model is prone to overgeneration due to lack of linguistic knowledge: the grammar may suggest more derivations than(More)
s Papers Clinical PCLB PCRB PCS PCLB PCRB PCS PCLB PCRB PCS autoparse(t&t) 91.97 87.82 80.88 85.45 67.20 59.26 97.48 88.30 85.89 autoparse(test) 92.71 88.33 81.84 87.57 68.78 62.70 97.48 87.73 85.21 oracle 99.72 94.59 94.37 98.94 84.13 83.33 99.89 98.39 98.39 Table 5: Performance (%) of negation scope finding on the three subcorpora by using automatic(More)
The bidirectional interation between pancreatic cancer (PanCa) and diabetes has been confirmed by epidemiological studies, which provide evidence-based medical support for further research into the mechanisms involved in the interaction. We reviewed the literature regarding the role of diabetes in the generation and progression of PanCa and the mechanism by(More)
Multiple lines of evidence suggest that a large portion of pancreatic cancer patients suffer from either hyperglycemia or diabetes, both of which are characterized by high blood glucose level. However, the underlying biological mechanism of this phenomenon is largely unknown. In the present study, we demonstrated that the proliferative ability of two human(More)
Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neuotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was(More)
There is increasing evidence that hepatocellular carcinoma (HCC) is inherently associated with the inflammatory process and the up-regulation of cytokines. Our study aimed at elucidating the role of the cytokine fractalkine in the process of HCC carcinogenesis. Expression of fractalkine in hepatocellular carcinoma cell line HepG2 was knocked-down by RNAi.(More)
The SCF/c-kit signaling plays an important role in invasion of c-kit-expressing tumor cells, however, the molecular mechanisms have not been studied yet. Using a pancreatic cancer model, we demonstrate that SCF/c-kit binding up-regulates the expression of invasion-related genes through the accumulation of HIF-1α. Furthermore, the expression of HIF-1α(More)