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A Hall-effect biosensor based on magnetic label detection is implemented in 0.18 μm CMOS. No external magnet, reference sensor or calibration is required. The sensor offset is suppressed to sub-μV by a mixed-signal feedback loop and correlated double sampling (CDS). Flicker noise and thermal noise are rejected by CDS and averaging. A single 4.5 μm bead is(More)
Rapid prototyping of microfluidic systems using a combination of double-sided tape and PDMS (polydimethylsiloxane) is introduced. PDMS is typically difficult to bond using adhesive tapes due to its hydrophobic nature and low surface energy. For this reason, PDMS is not compatible with the xurography method, which uses a knife plotter and various adhesive(More)
A compact and robust magnetic label detector for biomedical assays is implemented in 0.18-μm CMOS. Detection relies on the magnetic relaxation signature of a microbead label for improved tolerance to environmental variations and relaxed dynamic range requirement, eliminating the need for baseline calibration and reference sensors. The device includes(More)
A DNA extraction system was designed and fabricated using an AOM (aluminum oxide membrane) with 200 nm pores and PDMS microfluidic channels. The membrane was patterned using soft lithography techniques and SU-8 photolithography on the membrane. After making the pattern with SU-8, the AOM was observed using an SEM (scanning electro microscope) to verify the(More)
In 2014, we performed a nationwide survey in Korean radish fields to investigate the distribution and variability of Turnip mosaic virus (TuMV). Brassica rapa ssp. pekinensis sap-inoculated with three isolates of TuMV from infected radish tissue showed different symptom severities, whereas symptoms in Raphanus sativus were similar for each isolate. The(More)
BACKGROUND Synthetic biology aims to engineer biological systems for desired behaviors. The construction of these systems can be complex, often requiring genetic reprogramming, extensive de novo DNA synthesis, and functional screening. RESULTS Herein, we present a programmable, multipurpose microfluidic platform and associated software and apply the(More)