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Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.
  • M. Kim, G. Ryu, +9 authors Y. Jo
  • Biology, Medicine
  • Biochemical pharmacology
  • 1 November 2004
Cytokines that are released by infiltrating inflammatory cells around the pancreatic islets are involved in the pathogenesis of type 1 diabetes mellitus. Specifically, interleukin-1beta (IL-1beta)Expand
Exendin‐4 induction of Egr‐1 expression in INS‐1 β‐cells: Interaction of SRF, not YY1, with SRE site of rat Egr‐1 promoter
Glucagon‐like peptide‐1 (GLP‐1) induces several immediate early response genes such as c‐fos, c‐jun, and early growth response‐1 (Egr‐1), which are involved in cell proliferation and differentiation.Expand
The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells
Background: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascularExpand
Proximal cyclic AMP response element is essential for exendin-4 induction of rat EGR-1 gene.
Glucagon-like peptide-1 and its potent agonist exendin-4 induce several immediate early response genes (IEGs) that code for transcription factors implicated in cell proliferation, differentiation,Expand
Stereoselective additions of thiyl radicals to terminal ynamides.
Two complementary sets of conditions for radical additions of thiols to terminal ynamides are described. The use of 1 equiv of thiol affords the cis-beta-thioenamide adducts in rapid fashion (10 min)Expand
Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells.
Cytokines such as interleukin-1beta (IL-1beta) stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage. Meanwhile, glucagon-likeExpand
Second-generation DBFOX ligands for the synthesis of beta-substituted alpha-amino acids via enantioselective radical conjugate additions.
A set of second-generation DBFOX ligands possessing extended aryl or benzyl-type groups was synthesized. The requisite amino alcohols were either commercially available (DBFOX/Bn) or constructed viaExpand
GnRH agonist reduces estrogen receptor dimerization in GT1-7 cells: Evidence for cross-talk between membrane-initiated estrogen and GnRH signaling
17β-estradiol (E2), a key participant on the initiation of the LH surge, exerts both positive and negative feedback on GnRH neurons. We sought to investigate potential interactions between estrogenExpand
Curcumin inhibits poly(dA:dT)-induced IL-18 secretion by inhibiting the ASC oligomerization in human keratinocytes
Interleukin (IL)-18, a member of the IL-1 family, has been implicated in the development of a variety of inflammatory skin diseases. The binding of double-stranded (ds) DNA to absent in melanomaExpand
Stereoselective Additions of Thiyl Radicals to Terminal Ynamides.
Ynamides (I) give under two complementary sets of reaction conditions either (Z)- or (E)-β-thioenamides by reaction with thiols.